NAKAJIMA, Kenichi, MD, PhD, Clinical Professor, Department of Nuclear Medicine, Kanazawa University Hospital Present Position: My research activities include: au jardin de ma maisonOur major works published in Journals: [PDF file available, to take contact-]
  1. Nakajima K, Okuda K, Matsuo S, Yoshita M, Taki J, Yamada M, Kinuya S. Standardization of metaiodobenzylguanidine heart-to-mediastinum ratio using a calibration phantom: Effects of correction on normal databases and a multi-center study. Eur J Nucl Med Mol Imaging (in press)
  2. Nakajima K, Matsuo S, Okuyama C, Hatta M, Tsukamoto K, Nishimura S, Yamashina A, Nishimura T. Cardiac event risk in Japanese subjects estimated using gated myocardial perfusion imaging, in conjunction with diabetes mellitus and chronic kidney disease. Circ J (in press). Circ J (in press)
  3. Okuda K, Nakajima K, Matsuo S, Wakabayashi H, Taki J, Kinuya S. Cause of apical thinning on attenuation-corrected myocardial perfusion SPECT. Nucl Med Commun. 2011 Nov;32(11):1033-9.
  4. Nakajima K, Matsuo S, Okuda K, Wakabayashi H, Tsukamoto K, Nishimura T. Estimation of cardiac event risk by gated myocardial perfusion imaging and quantitative scoring methods based on a multi-center J-ACCESS database. Circ J 2011; 75:10, 2417-23. (Epub)
  5. Okuda K, Nakajima K, Hosoya T, Ishikawa T, Matsuo S, Kawano M, Taki J, Kinuya S. Quantification of myocardial perfusion SPECT using freeware package (cardioBull). Ann Nucl Med. 2011 Jun 23. [Epub ahead of print]
  6. Wakabayashi H, Nakajima K, Fukuoka M, Inaki A, Nakamura A, Kayano D, Kinuya S. Double-phase 131I whole body scan and 131I SPECT-CT images in patients with differentiated thyroid cancer: their effectiveness for accurate identification. Ann Nucl Med. 2011 Jul 2. [Epub ahead of print]
  7. Kim F, Yamada K, Inoue D, Nakajima K, Mizushima I, Kakuchi Y, Fujii H, Narumi K, Matsumura M, Umehara H, Yamagishi M, Kawano M. IgG4-related tubulointerstitial nephritis and hepatic inflammatory pseudotumor without hypocomplementemia. Intern Med. 2011;50(11):1239-44. Epub 2011 Jun 1.
  8. Okuyama C, Nakajima K, Hatta T, Nishimura S, Kusuoka H, Yamashina A, Nishimura T. Incremental prognostic value of myocardial perfusion single photon emission computed tomography for patients with diabetes and chronic kidney disease. Nucl Med Commun. 2011;32(10):913-9.
  9. Okuda K, Nakajima K, Hosoya T, Ishikawa T, Konishi T, Matsubara K, Matsuo S, Kinuya S. Semi-automated algorithm for calculating heart-to-mediastinum ratio in cardiac Iodine-123 MIBG imaging. J Nucl Cardiol. 2011;18(1):82-9
  10. Nakajima K. [Editorial] Visual versus quantitative assessment: a new viewpoint for cardiac function using motion tracking method. Circ J 2011;75: 57-8
  11. Nakajima K, Hasegawa M, Inaki A, Wakabayashi H, Hosoya T, Takehara K, Kinuya S. Esophageal transit study using a sliding sum image: Application to patients with probable and definite systemic sclerosis. Ann Nucl Med 2011;25:325-31 - Sliding Sum Imge Software for Windows PC available now.
  12. Yamasaki Y, Nakajima K, Kusuoka H, Izumi T, Kashiwagi A, Kawamori R, Shimamoto K, Yamada N, Nishimura T. Prognostic value of gated myocardial perfusion imaging for asymptomatic patients with type-2 diabetes: The J-ACCESS II investigation. Dibetes Care 2010;33(11) :2320-6
  13. Nakajima K, Matsuo S, Hasegawa M, Kinuya S, Takehara K. Identification of myocardial damage in systemic sclerosis: A nuclear cardiology approach. In: Special issue of vascular disease in systemic sclerosis. Int J Rheumatology 2010, Article ID 496509, 9 pages, 2010. doi:10.1155/2010/496509 [ Open Access download]
  14. Matsuo S, Nakajima K, Yamasaki Y, Kashiwagi A, Nishimura T. Prognostic value of normal stress myocardial perfusion imaging and ventricular function in Japanese asymptomatic patients with type 2 diabetes. Circ J. 2010;74(9):1916-21
  15. Usui Y, Chikamori T, Nakajima K, Hida S, Yamashina A, Nishimura T. Prognostic value of post-ischemic stunning as assessed by gated myocardial perfusion single-photon emission computed tomography: a subanalysis of the J-ACCESS study. Circ J. 2010 Aug;74(8):1591-9. Epub 2010 Jun 19
  16. (JSNM working group final report/ review article) Nakajima K. Normal values for nuclear cardiology: Japanese databases for myocardial perfusion, fatty acid and sympathetic imaging and left ventricular function. Ann Nucl Med 2010; 24:125-135 [Open Access download]
  17. Nakajima K, Nishimura T. Prediction of cardiac mortality and events by myocardial perfusion Imaging: Differences between Japan and American populations. In: Horizons in World Cardiovascular Research. Editors: Eleanor H. Bennington. Volume 2. 2010, Nova Science Publishers (Open Access).
  18. Nakajima K, Matsuo S, Kawano M, Matsumoto N, Hashimoto J, Yoshinaga K, Taki J, Okuda K. The validity of multi-center common normal database for identifying myocardial ischemia: Japanese Society of Nuclear Medicine working group database. Ann Nucl Med. 2010;24(2):99-105
  19. Watanabe S, Kahara T, Seto C, Uchiyama A, Abo H, Ishikura K, Nakajima K, Usuda R. Utility of follow-up of 131I-MIBG scintigraphy to screen pheochromocytoma. Intern Med. 2009;48(18):1711-2. Epub 2009 Sep 15.
  20. Nakajima K, Inaki A, Hiramatsu T, Hasegawa M, Fujimoto M, Takehara K, Kinuya S. Esophageal transit scintigraphy and structured questionnaire in patients with systemic sclerosis with endoscopically proven reflux esophagitis. Ann Nucl Med 2009; 23: 771-776
  21. Nakajima K, Yamasaki Y, Kusuoka H, Izumi T, Kashiwagi A, Kawamori R, Shimamoto K, Yamada N, Nishimura T. Cardiovascular events in Japanese asymptomatic patients with type 2 diabetes: A one-year interim report of a J-ACCESS 2 investigation using myocardial perfusion imaging. Eur J Nucl Med Mol Imaging 2009; 36:2049-2057
  22. Nakajima K, Okuda K, Kawano M, Matsuo S, Slomka P, Germano G, Kinuya S: The importance of population-specific normal database for quantification of myocardial ischemia: Comparison between Japanese 360 and 180-degree databases and a US database. J Nucl Cardiol 2009; 16:422-430
  23. Matsuo S, Nakajima K, Yamashina S, Sakata K, Momose M, Hashimoto J, Kumita S, Kawano M, Okuda K. Characterization of Japanese standards for myocardial sympathetic and metabolic imaging in comparison with perfusion imaging. Ann Nucl Med 2009; 23:517-522
  24. Okuda K, Nakajima K, Motomura N, Kubota M, Yamaki N, Maeda H, Matsuo S, Kinuya S. Attenuation correction of myocardial SPECT by scatter-photopeak window method in normal subjects. Ann Nucl Med 2009;23(5):501-6
  25. Momose M, Nakajima K, Nishimura T. Prognostic significance of stress myocardial gated SPECT among Japanese patients referred for coronary angiography: a study of data from the J-ACCESS database. Eur J Nucl Med Mol Imaging 2009; 36(8):1329-37
  26. Nakajima K, Kusuoka H, Nishimura S, Yamashina A, Nishimura T. Prognostic value of myocardial perfusion and ventricular function in a Japanese multicenter cohort study (J-ACCESS): the first-year total events and hard events Ann Nucl Med 2009; 23(4):373-81
  27. Kayano D, Nakajima K, Ohtake H, Kinuya S. Gated myocardial perfusion SPECT for preoperative risk stratification in patients with noncardiac vascular disease. Ann Nucl Med 2009; 23:173-81
  28. Matsuo S, Nakajima K, Okuda K, Kawano M, Ishikawa T, Hosoya T, Taki J, Kinuya S. Standardization of the heart-to-mediastinum ratio of iodine-123-labeled-meta-iodobenzylguanidine uptake using dual energy window method: Feasibility of correction from different camera-collimator combinations. Eur J Nucl Med Mol Imaging 2009; 36:560-566
  29. Kahara T, Nakajima K, Takahashi K, Iwaki N, Michigishi T, Usuda R. Accumulations in the salivary gland due to Tc-99m pertechnetate imaging improved after isotope therapy for Graves' disease. Intern Med. 2008;47(3):179-80. Epub 2008 Feb 1.
  30. Nakajima K, Yoshita M, Matsuo S, Taki J, Kinuya S. I-123 MIBG sympathetic imaging in Lewy-body diseases and related movement disorders. [Review] Q J Nucl Med 2008;52: 378-87.
  31. Nakajima K, Nishimura T. Prognostic table for predicting major cardiac events based on J-ACCESS investigation. Ann Nucl Med 2008; 22:891-897 [Heart Risk Table; sample figures]
  32. Kizu H, Takayama T, Tsushima H, Noguchi A, Nakajima K, Onoguchi M, Kinuya S. Localization of metastases from malignant pheochromocytoma in patients undergoing 131I-MIBG therapy with manually fused 123I-MIBG SPECT and CT images. J Nuc Med Tech 2008 36; 186-8
  33. Nakajima K, Tamaki N, Kuwabara Y, Kawano M, Matsunari I, Taki J, Nishimura S, Yamashina A, Ishida Y, Tomoike H. Prediction of functional recovery after revascularization using quantitative gated myocardial perfusion SPECT: a multi-center cohort study in Japan. Eur J Nucl Med Mol Imaging 2008; 35:2038-2048 [pubmed]
  34. Akhter N, Nakajima K, Okuda K, Matsuo S, Yoneyama T, Taki J, Kinuya S. Regional wall thickening in gated myocardial perfusion SPECT in a Japanese population: Effect of sex, radiotracer, rotation angles and frame rates. Eur J Nucl Med Mol Imaging 2008; 35: 1608-1615 [pubmed] [Springer]
  35. Matsuo S, Nakajima K, Horie M, Nakae I, Nishimura T; The J-ACCESS Investigators. Prognostic value of normal stress myocardial perfusion imaging in Japanese population. Circ J 2008;72(4):611-617 [pubmed]
  36. Nishimura T, Nakajima K, Kusuoka H, Yamashina A, Nishimura S. Prognostic study of risk stratification among Japanese patients with ischemic heart disease using gated myocardial perfusion SPECT: J-ACCESS study. Eur J Nucl Med Mol Imaging 2008; 35:19-28. [pubmed]
  37. Nakajima K, Matsubara K, Ishikawa T, Motomura N, Maeda R, Akhter N, Okuda K, Taki J, Kinuya S. Correction of I-123-labeled meta-iodobenzylguanidine uptake with multi-window methods for standardization of the heart to mediastinum ratio. J Nucl Cardiol 2007; 14:843-851. [pubmed]
  38. Nakajima K, Kumita S, Ishida Y, Momose M, Hashimoto J, Morita K, Taki J, Yamashina S, Maruno H, Ogawa M, Kubota M, Takahashi M, Odagawa T, Yokozuka K. Creation and characterization of Japanese standards for myocardial perfusion SPECT: Database from Japanese Society of Nuclear Medicine Working Group. Ann Nucl Med 2007; 21: 505-511 [Springer/ANM]
  39. Nakajima K, Kusuoka H, Nishimura S, Yamashina A, Nishimura T. Normal limits of ejection fraction and volumes by gated SPECT based on J-ACCESS database in clinically normal patients without cardiac events. Eur J Nucl Med Mol Imaging 2007;34: 1088-1096 [pubmed]
  40. Kusuoka H, Nishimura S, Yamashina A, Nakajima K, Nishimura T. Surveillance study for creating the national clinical database related to ECG-gated myocardial perfusion SPECT of ischemic heart disease: J-ACCESS study design. Ann Nucl Med 2006;20:195-202. [pubmed]
  41. Nakajima K, Kawano M, Hasegawa M, Taki J, Fujimoto M, Takehara K, Tonami N. Myocardial damages in systemic sclerosis detected by gated myocardial perfusion SPECT and sympathetic imaging. Circ J 2006;70:1481-1487 [pubmed]
  42. Nakajima K, Taki J, Yoneyama T, Fukuoka M, Kayano D, Tonami N. Fluctuation of adenosine concentration by modes of intravenous infusion based on mathematical simulation and experiments. Ann Nucl Med. 2006 ;20:485-91
  43. Nakajima K, Nishimura T. Inter-institution preference-based variability of ejection fraction and volumes using quantitative gated SPECT with 99mTc-tetrofosmin: a multicentre study involving 106 hospitals. Eur J Nucl Med Mol Imaging 2006; 33:127-133
  44. Nakajima K, Kawano M,Kinami S, Fujimura T, Miwa K, Tonami N. Dual-radionuclide simultaneous gastric emptying and bile transit study after gastric surgery with double-tract reconstruction. Ann Nucl Med 2005; 19:185-191
  45. Nakajima K, Kawano M, Kinuya K, Sato S, Takehara K, Tonami N. The diagnostic value of oesophageal transit scintigraphy for evaluating the severity of oesophageal complications in systemic sclerosis. Nucl Med Commun 2004;25:375-81. Keywords: esophageal transit study, systemic sclerosis, esophageal dysmotility [pubmed]
  46. Nakajima K, Higuchi T, Taki J, Kawano M, Tonami N. Accuracy of ventricular volume and ejection fraction measured by gated myocardial SPECT: Comparison of 4 software programs. J Nucl Med 2001;42:1571-1578
  47. Taki J, Fujino S, Nakajima K, Matsunari I, Okazaki H, Saga T, Bunko H, Tonami N. 99mTc-sestamibi retention characteristics during pharmacologic hyperemia in human myocardium: Comparison with coronary flow reserve measured by doppler flowire. J Nucl Med 2001;42:1457-1463
  48. Higuchi T, Nakajima K, Taki J, Kinuya S, Bunko H, Tonami N. Assessment of left ventricular systolic and diastolic function based on the edge detection method with myocardial ECG-gated SPET. Eur J Nucl Med 2001; 28:1512-1516
  49. Nakajima K, Taki J, Kawano M, Higuchi T, Sato S, Nishijima C, Takehara K, Tonami N. Diastolic dysfunction in patients with systemic sclerosis detected by gated myocardial perfusion SPECT: an early sign of cardiac involvement. J Nucl Med 2001;42:183-188.
  50. Nakajima K, Taki J, Higuchi T, Kawano M, Taniguchi M, Maruhashi, K, Sakazume S, Tonami N. Gated SPET quantification of small hearts: Mathematical simulation and clinical application. Eur J Nucl Med 2000;27:1372-1379
  51. Taki J, Nakajima K, Hwang EH, Matsunari I, Komai K, Yoshita M, Sakajiri K, Tonami N. Peripheral sympathetic dysfunction in patients with Parkinson's disease without autonomic failure is heart sensitive and disease specific. Eur J Nucl Med 2000; 27: 566-573
  52. Ikeda E, Taki J, Nakajima K, Tonami N. Thallium-201 SPECT with triple-headed gamma camera for differential diagnosis of small pulmonary nodular lesion 20 mm in diameter or smaller. Ann Nucl Med 2000; 14:91-95
  53. Taki J, Muramori A, Kinuya S, Nakajima K, Matsunari I, Miyazaki Y, Murata Y, Tonami N. Forward output measurement with first-pass technique using 99mTc-labeled myocardial perfusion imaging agent. J Nucl Med 1999; 40: 1874-1881
  54. Nakajima K, Kinuya K, Mizutani Y, Hwang EH, Michigishi T, Tonami N, Kobayashi K: Simple scintigraphic parameters with Tc-99m galactosyl human serum albumin for clinical staging of chronic hepatocellular dysfunction. Ann Nucl Med 1999; 13: 5-11
  55. Taki J, Matsunari I, Nakajima K, Tonami N. BMIPP compared with thallium redistribution. Int J Cardiac Imaging 1999; 15: 49-59
  56. Hwang EH, Taki J, Shuke N, Nakajima K, Kinuya S, Konishi S, Michigishi T, Aburano T, Tonami N. Preoperative assessment of residual hepatic functional reserve using 99mTc-DTPA-galactosyl-human serum albumin dynamic SPECT. J Nucl Med 1999; 40: 1644-1651
  57. Taki J, Yamamoto W, Nakajima K, Ichiyanagi K, Kato H, Furukawa M, Tonami N. Prediction of prognosis in peripheral nerve paralysis using submandibular gland scintigraphy. J Nucl Med 1998; 39: 716-721.
  58. Taki J, Yasuhara S, Takamatsu T, Nakajima K, Tatami R, Ishise S, Matsunari I, Takayama T, Tonami N. Value of iodine-123 metaiodobenzylguanidine scintigraphy in patients with vasospastic angina. Eur J Nucl Med 1998; 25: 229-234
  59. Hwang EH, Taki J, Yasue S, Fujimoto M, Taniguchi M, Matsunari I, Nakajima K, Shiobara S, Ikeda T, Tonami N. Absent myocardial iodine-123-BMIPP uptake and platelet/monocyte CD36 deficiency. J Nucl Med 1998; 39: 1681-1684
  60. Nakajima K, Taki J, Michigishi T, et al: Superiority of triple-detector SPET over single-and dual-detector systems in the minimization of motion artefacts. Eur J Nucl Med 1998; 25, 1545-1551
  61. Nakajima K, Taki J, Yamamoto W, et al: Myocardial fatty acid imaging with I-123 labelled 9-methyl-branched pentadecanoic acid (9MPA) using SPET. Nucl Med Commun 1998; 19:839-847
  62. Nakajima K, Taki J, Yamamoto W, et al: Effect of 360. and 180. rotation SPET acquisition on myocardial polar map: Comparison of 201Tl, 99Tcm- and 123I-labelled radiopharmaceuticals. Nucl Med Commun 1998; 19: 315-625
  63. Kuji I, Sumiya H, Taki J, Nakajima K, Yokoyama K, Kinuya S, Kinuya K, Ichikawa A, Konishi S, Michigishi T, Tonami N. Intense Ga-67 uptake in adenosquamous carcinoma of the pancreas. Ann Nucl Med 1997;11: 41-43
  64. Nakajima K, Taki J, Matsuyama T, et al: Functional imaging of gated Tc-99m tetrofosmin study as a simple method to quantify ventricular wall motion. Ann Nucl Med 1997; 11: 87-94
  65. Taki J, Nakajima K, Matsunari I, Bunko H, Takata S, Kawasuji M, Tonami N. Assessment of improvement of myocardial fatty acid uptake and function after revascularization using iodine-123-BMIPP. J Nucl Med 1997; 38: 1503-1510
  66. Taki J, Ichikawa A, Nakajima K, Kawasuji M, Tonami N. Comparison of flow capacities of arterial and venous grafts for coronary artery bypass grafting: evaluation with exercise thallium-201 single-photon emission tomography. Eur J Nucl Med 1997; 24: 1487-1493
  67. Nakajima K, Shuke N, Nitta Y, et al. Comparison of 99Tcm-pyrophosphate, 201T1 perfusion, 123I-labelled methyl-branched fatty acid and sympathetic imaging in acute coronary syndrome. Nucl Med Commun 1995; 16: 494-503.
  68. Nakajima K, Shimizu K, Taki J, et al. Utility of iodine-123-BMIPP in the diagnosis and follow-up of vasospastic angina. J Nucl Med 1995; 36: 1934-40.
  69. Nakajima K, Taki J, Tonami N and Hisada K. Decreased 123I-MIBG uptake and increased clearance in various cardiac diseases. Nucl Med Commun 1994; 15: 317-23.
  70. Taki J, Nakajima K, Matsunari I, et al. Impairment of regional fatty acid uptake in relation to wall motion and thallium-201 uptake in ischaemic but viable myocardium: assessment with iodine-123-labelled beta-methyl-branched fatty acid. Eur J Nucl Med 1995; 22: 1385-92.
  71. Taki J, Nakajima K, Shimizu M, Tonami N and Hisada K. Left ventricular functional reserve in nonobstructive hypertrophic cardiomyopathy: evaluation by continuous left ventricular function monitoring. J Nucl Med 1994; 35: 1937-43.
  72. Taki J, Nakajima K, Bunko H, et al. Twenty-four-hour quantitative thallium imaging for predicting beneficial revascularization. Eur J Nucl Med 1994; 21: 1212-7.
  73. Taki J, Nakajima K, Muramori A, et al. Left ventricular dysfunction during exercise in patients with angina pectoris and angiographically normal coronary arteries (syndrome X) [published erratum appears in Eur J Nucl Med 1994 Jul;21(7):712]. Eur J Nucl Med 1994; 21: 98-102.
  74. Nakajima K, Taki J, Shuke N, et al. Myocardial perfusion imaging and dynamic analysis with technetium-99m tetrofosmin. J Nucl Med 1993; 34: 1478-84.
  75. Nakajima K, Taki J, Matsudaira M, et al. High-resolution cardiac SPET study using fanbeam collimators in infants. Nucl Med Commun 1992; 13: 604-8.
  76. Nakajima K, Shuke N, Taki J, et al. A simulation of dynamic SPECT using radiopharmaceuticals with rapid clearance. J Nucl Med 1992; 33: 1200-6.
  77. Nakajima K, Taki J, Ohno T, et al. Assessment of right ventricular overload by a thallium-201 SPECT study in children with congenital heart disease. J Nucl Med 1991; 32: 2215-20.
  78. Nakajima K, Taki J, Bunko H, et al. Dynamic acquisition with a three-headed SPECT system: application to technetium 99m-SQ30217 myocardial imaging. J Nucl Med 1991; 32: 1273-7.
  79. Nakajima K, Taki J, Bunko H, et al. Error of uptake in dual energy acquisition with 201Tl and 123I labeled radiopharmaceuticals. Eur J Nucl Med 1990; 16: 595-9.
  80. Nakajima K, Fotouhi F, Taki J, et al. Estimation of right ventricular pressure by 201Tl scintigraphy in paediatric cardiac disease. Nucl Med Commun 1990; 11: 677-84.
  81. Nakajima K, Bunko H, Taki J, et al. Quantitative analysis of 123I-meta-iodobenzylguanidine (MIBG) uptake in hypertrophic cardiomyopathy. Am Heart J 1990; 119: 1329-37.
  82. Other works:
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Update: Aug 13, 2010
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