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平成２２年度 教室業績 著書・論文
  • 1) 大江真琴（東京大学・看護学専攻），（大桑麻由美：金沢大学看護学講座），（真田弘美：東京大学看護学専攻老年看護学・創傷看護学分野），（須釜淳子：金沢大学看護学講座），（稲垣美智子：金沢大学看護学講座），笠原善仁，（田端恵子：浅ノ川千木病院），（仲上豪二朗），（西澤知江：東京大学医学部附属病院看護部）．
  • Difference of foot manifestations between young, adult, and bedridden elderly with diabetes : a cross-sectional observational study.
  • 看護実践学会誌 Vol.2,No.1,p19-27,2010
  • （教室業績第1950号）
  • 2) (河島 尚志:東京医科大学小児科),(金兼 弘和:富山大学小児科),(森 雅亮: 横浜市立大学小児科),(今中 啓之:鹿児島大学小児科),(新庄 正宜:慶応大学小児 科),(村田 卓士:大阪医科大学小児科),笠原 善仁,(谷口 義弘:福井赤十字病院 小児科),(杉田 完爾:山梨大学小児科),(宮脇 利男).
  • 本邦における高 IgD 症候群のアンケート調査(Hyper IgD and periodic fever syndrome in Japan)
  • 東京医科大学雑誌 Vol.68,No.2,p235-238,2010
  • (教室業績第1951号)
  • 3) (金兼 弘和:富山大学医学部小児科),和田 泰三,(木村 宏:名古屋大学医学部 ウイルス学).
  • 小児皮膚疾患 EB ウイルス感染症.
  • 小児科 Vol.51,No.5,p54-55,2010
  • (教室業績第1952号)
  • 4) (Yoshida Y, Nakada M : Department of Neurosurgery, Graduate School of Medical Science, Kanazawa University),(Sugimoto N : Department of Physiology, Graduate School of Medical Science, Kanazawa University),(Harada T, Hayashi Y, Kita D, Uchiyama N, Hayashi Y), Yachie A,(Takuwa Y),(Hamada J).
  • Sphingosine-1-phosphate receptor type 1 regulates glioma cell proliferation and correlates with patient survival.
  • International Journal of Cancer Vol.126,No.10,p2341-52,2010
  • (教室業績第1953号)
  • 5) (金兼 弘和,新井真理奈:富山大学医学部小児科),谷内江昭宏.
  • 慢性活動性 EB ウイルス感染症.
  • モダンメディア Vol.56,No.5,p93-9,2010
  • (教室業績第1954号)
  • 6) 栂 暁子,清水 正樹,馬!新太郎,刀祢 裕美,西村 良成,和田 泰三, 東馬 智子,犀川 太,笠原 善仁,谷内江昭宏.
  • Viridans streptococcal shock syndrome を合併した慢性活動性 EB ウイルス感染症 の1例.
  • 小児科 Vol.51,No.6,p837-842,2010
  • (教室業績第1955号)
  • 7) Nikolov NP, Shimizu M, Cleland S, Bailey D, Aoki J, Strom T, Schwartzberg PL, Candotti F, Siegel RM.
  • 7Systemic autoimmunity and defective Fas ligand secretion in the absence of the Wiskott-Aldrich syndrome protein.
  • 7Blood Vol.16,No.5,p740-7,2010
  • (教室業績第1956号)
  • 8) Morita T, Ashida A, Fujieda M, Hayashi A, Maeda A, Ohta K, Shimizu M, Sekine T, Igarashi T, Tamai H, Wakiguchi H.
  • Four cases of postrenal renal failure induced by renal stone associated with rotavirus infection.
  • Clinical nephrology Vol.73,No.5,p398-402,2010
  • (教室業績第1957号)
  • 9) 太田 邦雄.
  • -研修医のための小児診療手技の基本-気道,胸部 電気ショック,電気的除細動, AED.
  • 小児科診療 Vol.73,No.5,p79-783,2010
  • (教室業績第1958号)
  • 10) 清水 正樹.>/
  • Microangiopathic antiphospholipid syndrome.
  • 小児リウマチ Vol.2,No.1,p34-39,2010
  • (教室業績第1960号)
  • 11) Shimizu M, Yokoyama T, Wada T, Yachie A.
  • Bicipital synovial cyst in systemic-onset juvenile idiopathic arthritis.
  • The Journal of Pediatrics Vol.157,No.1,p168,2010
  • (教室業績第1961号)
  • 12) (Seki M : Department of Allergy and Immunology, Gunma Children’s Medical Center, 79 Shimohakoda, Hokkitsu-machi, Shibukawa, Gunma 37-857, Japan),(Kimura H : National Institute of Infectious Diseases, Musashimurayama, Japan), (Mori A : Department of Allergy, National Hospital Organization, Sagamihara National Hospital, Sagamihara, Kanagawa, Japan), (Shimada A : Departments of Hematology and O n c o l o g y , G u n m a C h i l d r e n ’s M e d i c a l C e n t e r , S h i b u k a w a , G u n m a , J a p a n ), (Yamada Y), (Maruyama K : Departments of Internal Medicine and, Gunma Children’s Medical Center, Shibukawa, Gunma, Japan),(Hayashi Y),(Agematsu K : Department of Pediatrics, Shinshu University, Graduate School of Medicine, Matsumato, Nagano, Japan),(Morio T : Department of Pediatrics and Developmental Biology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan), Yachie A,(Kato M).
  • Prominent eosinophilia but less eosinophil activation in a patient with Omenn syndrome.
  • Pediatrics International Vol.52,No.4,p196-19,2010
  • (教室業績第1962号)
  • 13) 西尾さやか,清水 正樹,佐藤 啓,横山 忠史,小幡 美智,三谷 裕介, 橋田 暢子,太田 和秀,谷内江昭宏.
  • ミコフェノール酸モフェチル(MMF)関連腸炎,ミゾリビン関連膵炎を呈した腎 移植後巣状糸球体硬化症の1例.
  • 日本小児腎不全学会雑誌 Vol.30,p195-197,2010
  • (教室業績第1963号)
  • 14) Shimizu M, (Kitagawa K : Division of Nephrology, Department of Laboratory Medicine, School of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University), Nishio S, Yokoyama T,(Furuichi K:Division of Blood Purification, Kanazawa University Hospital), (Ohta K : Department of Pediatrics, Kanazawa Medical Center), Wada T, Yachie A.
  • Successful treatment of recurrent focal segmental glomerulosclerosis after renal transplantation by lymphocytapheresis and rituximab.
  • Transplant international Vol.23,No.9,p53-5.2010
  • (教室業績第1964号)
  • 15) Shimizu M, Yokoyama T,(Yamada K : Department of Pediatrics, Tonami General Hospital, Tonami), (Kaneda H : Department of Pediatrics, Toyama City Hospital, Yoyama), (Wada H : Department of Pediatrics, Noto General Hospital, Nanao), Wada T, Toma T,(Ohta K : Department of Pediatrics, Kanazawa Medical Center), Kasahara Y, Yachie A.
  • Distinct cytokine profiles of systemic-onset juvenile idiopathic arthritis-associated macrophage activation syndrome with particular emphasis on the role of interleukin-18in its pathogenesis.
  • Rheumatology(Oxford) Vol.49,No.9,p1645-53,2010
  • (教室業績第1965号)
  • 16) 太田 邦雄.
  • -新しい小児救急医学に向けた変革 小児救命・集中治療医学としての再定義- 小児救急医療確立のためのシステム整備 予防.
  • 救急医学 Vol.34,No.9,p99-101,2010
  • (教室業績第1966号)
  • 17) 和田 泰三.
  • 小児の Epstein-Barr ウイルス関連リンパ増殖性疾患. Epstein-Barr Virus-associated lymphoproliferative diseases in children.
  • 金沢大学十全医学会雑誌 Vol.19,No.3,p15-19,2010
  • (教室業績第1967号)
  • 18) (Kita D, Hayashi Y, Watanabe T : Department of Neurosurgery, Kanazawa University Hospital),(Korshunov A, Von Deimling A : Department of Neuropathology, Institute of Pathology, Ruprecht-Karls-Universitaet Heidelberg, Heidelberg, Germany), (Nakada M), Kasahara Y, (Zen Y : Department of Neurosurgery, Pathology, Kanazawa University Hospital),(Hamada J, Hayashi Y).
  • Secondary anaplastic astrocytoma developing in a young adult with autoimmune lymphoproliferative syndrome(ALPS).
  • Neuropathology and Applied Neurobiology Vol.10,11/j.1365-290,2010
  • (教室業績第1969号)
  • 19) 太田 邦雄. -肺高血圧症の臨床における最新薬物治療-循環器専門医が診る肺高血圧症
  • 全身性強皮症に合併した肺動脈性肺高血圧症に対するボセンタンの効果.
  • Modern Physician Vol.30,p70-73,2010
  • (教室業績第1970号)
  • 20) (Ishida K : Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama), (Kaneda N : Department of Pediatrics, Toyama City Hospital), ( U e m u r a O : D e p a r t m e n t o f P e d i a t r i c N e p h r o l o g y , A i c h i C h i l d r e n ’s H e a l t h a n d Medical Center),(Ushijima K : Department of Pediatrics, Yokkaichi City Hospital), (Ohta K : Department of Pediatrics, Kanazawa Medical Center),(Goto Y : Kidney Center Pediatrics, Nagoya Daini Red Cross Hospital), (Satomura K : Division of Nephrology and Bone Metabolism, Department of Pediatrics, Osaka Medical Center and Research Institute for Maternal and Child Health), Shimizu M,(Fujieda M: Department of Pediatrics, Kochi Medical School, Kochi University),(Morooka M: Department of Pediatrics, Fujita Health University), (Yamada T), (Yamada M : Department of Pediatric Nephrology, Shizuoka Children’s Hospital)(Wada N), (Takaai M),(Hashimoto Y).
  • Evaluation of Limited Sampling Designs to Estimate Maximal Concentration and Area under the Curve of Mizoribine in Pediatric Patients with Renal Disease.
  • Drug Metabolism and Pharmacokinetics Vol.26,No.1,p71-78,2011
  • (教室業績第1971号)
  • 21) 横山 忠史,清水 正樹,土市 信之,長沖 優子,(水野 和徳:金沢医療センター 小児科),井上 巳香,前馬 秀昭(,酒詰 忍,太田 和秀),藤木 俊寛(,田村賢太郎: 富山県立中央病院小児科),中山 祐子,(東山 弘幸,藤田 修平,市村 昇悦, 二谷 武,五十嵐 登,畑崎 喜芳),谷内江昭宏.
  • ロタウイルス性胃腸炎における尿細管機能障害に関する検討.
  • 日本小児科学会雑誌 Vol.14,No.10,p1542-1549,2010
  • (教室業績第1972号)
  • 22) 前馬 秀昭.
  • [第72回日本血液学会]~PUVA 処置樹状細胞投与~GVHD の抑制が可能か.
  • Medical Tribune Vol.43,No.4,p.30,2010
  • (教室業績第1973号)
  • 23) Shimizu M, Tone Y, Toga A, Yokoyama T, Wada T, Toma T, Yachie A.
  • Colchicine-responsive chronic recurrent multifocal osteomyelitis with MEFV mutations : a variant of familial Mediterranean fever?
  • Rheumatology(Oxford) Vol.49,No.1,p221-3,2010
  • (教室業績第1974号)
  • 24) Wada T, Mase S, Shibata F, Shimizu M, Toma T, Yachie A.
  • Differential resistance to antiviral drugs in an immunocompromised patient with cytomegalovirus encephalitis.
  • Journal of Clinical Virology Vol.49,No.3,p23-4,2010
  • (教室業績第1975号)
  • 25) ( R a d h a k r i s h n a n N , Y a d a v S P , S a c h d e v a A : D e p a r t m e n t o f P e d i a t r i c s , P e d i a t r i c Hematology Oncology and BMT Unit), (Pruthi PK : Department of Pediatrics, Pediatric Nephrology Unit), (Sawhney S : Department of Pediatrics, Pediatric Rheumatology Unit, Centre for Child Health),(Piplani T : Department of CT Scan and MRI, Sir Ganga Ram Hospital, New Delhi, India), Wada T, Yachie A.
  • Human heme oxygenase-1deficiency presenting with hemolysis, nephritis, and asplenia.
  • Journal of Pediatric Hematology/Oncology Vol.3,No.1,p74-78,2011
  • (教室業績第1977号)
  • 26) Wada T, Tone Y, Shibata F, Toma T, Yachie A.
  • Delayed wound healing in leukocyte adhesion deficiency type1.
  • The Journal of Pediatrics Vol.158,No.2,p342,2011
  • (教室業績第1978号)
  • 27) 斉藤 剛克.
  • 特集-小児感染症 なぜ繰り返す,なぜ治らない-細菌性心内膜炎.
  • 小児内科 Vol.43,No.2,p24-248,2011
  • (教室業績第1980号)
  • 28) 笠原 善仁.
  • 特集-小児感染症 なぜ繰り返す,なぜ治らない-遭遇する頻度の高い感染症 EB ウイルス感染症.
  • 小児内科 Vol.43,No.2,p252-25,2011
  • (教室業績第1981号)
  • 29) (Takagi M : Department of Pediatrics and Developmental Biology, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan), (Shinoda K : Department of Pediatrics, Gifu Municipal Hospital, Gifu, Japan),(Piao J, Mitsuiki N), (Takagi M),(Matsuda K : Department of Laboratory Medicine, Shinshu University School of Medicine, Nagano, Japan), (Muramatsu H, Doisaki S : Department of Pediatrics, Nagoya University Graduate School of Medicine, Aichi, Japan), (Nagasawa M, Morio T), Kasahara Y,(Koike K : Department of Pediatrics, Shinshu University School of Medicine, Nagano, Japan),(Kojima S),(Takao A),(Mizutani S).
  • Autoimmune lymphoproliferative syndrome-like disease with somatic KRAS
  • mutation. Blood Vol.17,No.10,p287-90,2011
  • (教室業績第1982号)
学位論文
  • 30)Toga A, Wada T, Sakakibara Y, Mase S, Araki R, Tone Y, Toma T,(Kurokawa T : Department of Internal Medicine , Toyama Prefectural Central Hospital ), (Yanagisawa R:Department of Pediatrics, Shinshu University School of Medicine, Matsumoto), (Tamura K, Nishida N, Taneichi H, Kanegane H : Department of Pediatrics, Graduate School of Medicine, University of Toyama), Yachie A.
  • Clinical Significance of Cloned Expansion and CD5 Down-Regulation in Epstein- Barr Virus( EBV )-infected CD8+ T Lymphocytes in EBV-Associated Hemophagocytic Lymphohistiocytosis.
  • The Journal of Infectious Diseases Vol.201,No.12,p1923-32,2010
  • (教室業績第1959号)
    • Abstract
    Epstein-Barr virus(EBV)is the pathogen that most commonly triggers infection- associated hemophagocytic lymphohistiocytosis (HLH) and ectopically infects CD8+ T cells in EBV-associated HLH(EBV-HLH). We recently described an EBV-HLH patient who had a clonally expanded population of EBV-infected CD8+ T cells with CD5down-regulation. To determine whether this finding could serve as a useful marker for EBV-HLH, we investigated5additional patients. We found a significant increase in the subpopulation of CD8+ T cells with CD5 down- r e g u l a t i o n a n d b r i g h t h u m a n l e u k o c y t e a n t i g e n ( H L A )- D R e x p r e s s i o n i n a l l patients with EBV-HLH but not in patients with infectious mononucleosis or in control subjects. Such T cells were frequently found to be larger cells that stained positive for a specific T cell receptor VB. We also demonstrated that those cells were the major cellular target of EBV, and their numbers progressively declined in parallel with the serum ferritin levels. All together, our findings reveal the immunophenotypic characteristics of EBV-infected CD8+ T cells and may provide a valuable tool for the diagnosis of EBV-HLH.
  • 31)Shibata F.
  • Paradoxical inhibition of basophil degranulation by excess binding of a cedar pollen allergen, Cryj1.
  • 金沢大学十全医学会雑誌 Vol.19,No.3,p82-90,2010
  • (教室業績第1968号)
    • Abstract
    「Abstract」Background : Repeated exposure to allergens leads to tolerance in type I allergy. However, its mechanism is largely unknown at cellular level. Basophil stimulation test serves as a sensitive method to evaluate allergen- specific activation of basophils. It has been reported that basophil stimulation results in typical bell-shaped dose-response characteristics with inhibition of activation at high concentrations. However, there has been no study evaluating the dose-effect of allergen binding directly. Objectives : To disclose relationships between allergen dose and binding, parameters of basophil activation and severity of the clinical symptoms. Methods : Peripheral blood was obtained from volunteers with proved cedar pollen allergy. Basophil stimulation test was performed with different concentrations of biotin-conjugated cedar pollen antigen, Cryj1. Cryj1 binding, expression of surface antigens, and release of mediators were determined simultaneously. Severity of symptom was evaluated by scoring nasal, eye and throat symptoms and QOL of the subjects. Results : In all cases, bell-shaped dose-response was obtained for the expression of basophil granular proteins LAMP1, LAMP2and CD63on cell surface and release of mediators. In contrast, expression of the surface antigen CD203c and Cryj1 binding increased dose dependently without high-dose inhibition. Basophil activation was induced at very minute level of Cryj1 binding and the differences in dose-response profile reflected the level of inhibition at higher Cryj1 concentration. The levels of inhibition inversely correlated with the severity scores of the clinical symptoms. Conclusions : Basophil activation is induced at very low level of allergen binding and inhibited at high allergen level by individually different manner.
  • 32)Inoue M, Kasahara Y, Okajima M, Wada T, Toma T, Shimizu M, Koizumi S, Yachie A.
  • Accelerated production of muliple cytokines and chemokines by Epstein-Barr virus-infected natural killer cells and T cells.
  • 金沢大学十全医学会雑誌 Vol.19,No.4,p154-163,2010
  • (教室業績第1976号)
    • Abstract Ectopic Epstein-Barr virus(EBV)infection in natural killer(NK)cells and T cells is associated with hemophagocytic lymphohistiocytosis, chronic active EBV infection(CAEBV)with T/NK cell proliferation, and malignant lymphoma. We newly established seven EBV-infected NK cell lines and two T cell receptor (TCR)γδ+ T cell lines from patients with CAEBV and NK cell leukemia. To identify the cytokines and chemokines produced by EBV+ NK cells or T cells,79 soluble factors were screened in the supernatant of theses cell lines by cytokine antibody array. EBV+ NK cells and T cells and shortly cultured EBV+ NK cells produced a significantly greater amount of four type 1 inflammatory cytokines, namely, interferon-γ, interleukin(IL)-6, oncostatin M, and IL-8, two type 2 cytokines, namely, IL-13 and granulocyte-macrophage colony-stimulating factor (GM-CSF), and three chemokines, namely, I-309/CC chemokine ligand(CCL)1, monocyte chemoattractant protein-1(MCP-1)/CCL2, and regulated on activation, normal T cell expressed and secreted(RANTES)/CCL5, compared to normal activated EBV-negative NK cells or T cells and EBV-positive B cell lines. This accelerated production of multiple cytokines and chemokines in EBV-infected NK /T cells may be related to the pathogenesis of EBV-associated disease with proliferation of EBV-infected NK cells or T cells.
  • 33)Asai E, Wada T, Sakakibara Y, Toga A, Toma T, Shimizu T, Nampoothiri S, Imai K, Nonoyama S, Morio T, Muramatsu H, Kamachi Y, Ohara O, Yachie A.
  • Analysis of mutations and recombination activity in RAG-deficient patients.
  • Clinical Immunology Vol.138,No.2,p172-7,201
  • (教室業績第1979号)
    • Abstract Mutations in the recombination activating genes(RAG1or RAG2)can lead to a variety of immunodeficiencies. Herein, we report5cases of RAG deficiency from 5families : 3of Omenn syndrome,1of severe combined immunodeficiency, and1 of combined immunodeficiency with oligoclonal TCRγδ+ T cells, autoimmunity and cytomegalovirus infection. The genetic defects were heterogeneous and included6novel RAG mutations. All missense mutations except for Met43Ile in RAG2 were located in active core regions of RAG1 or RAG2. V(D)J recombination activity of each mutant was variable, ranging from half of the wild type activity to none, however, a significant decrease in average recombination activity was demonstrated in each patient. The reduced recombination activity of Met43Ile in RAG2may suggest a crucial role of the non-core region of RAG2in V(D)J recombination. These findings suggest that functional evaluation together with molecular analysis contributes to our broader understanding of RAG deficiency.